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A study of anthraquinone dyes as candidates for nomination to the National Cancer Institute (NCI) Chemical Selection Working Group (CSWG) for carcinogenesis bioassay is described. The preliminary candidate list of dyes was provided by the U.S. Operating Committee (USOC) of the Ecological and Toxicological Association of the Dyestuffs Manufacturing Industry (ETAD). After the identification and elimination of the chemicals considered previously by the CSWG, already tested adequately, or on test currently, information on the remaining candidates was evaluated according to such factors as chemical structure, potential exposure, and suspicion of carcinogenicity. On the basis of these considerations, 16 chemicals were judged to be the best candidates for testing. Twelve chemicals were nominated for carcinogenesis bloassay; four for inclusion in the National Toxicology Program (NTP) Short Term Testing Program.
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Sigman et al. (1985) studied this question.
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