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September 28, 2012SLEEPOpen Access

Adenotonsillectomy increases BRS in children with severe OSAS, though some parameters remain below healthy controls.

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Why the study?

Does adenotonsillectomy improve baroreflex sensitivity in children with severe obstructive sleep apnea?

Population

Children with severe obstructive sleep apnea syndrome and matched healthy non-snoring controls

Comparison

Adenotonsillectomy vs Matched healthy non-snoring controls

Design

Editorial

Follow-up

6 months

Key result

Adenotonsillectomy in children with severe OSAS increased most baroreflex sensitivity parameters at 6 months, though some indices remained lower than healthy controls.

Authors

HMHiren MuzumdarRARaanan Arens

Discussion

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Member takes

Overview

May support adenotonsillectomy for partial autonomic recovery in severe pediatric OSAS; leaves open durability of benefits and need for longer-term trials.

Structured PICO

Does adenotonsillectomy improve baroreflex sensitivity in children with severe obstructive sleep apnea?

P
Population
Children with severe obstructive sleep apnea (apnea-hypopnea index > 5/hour) and matched healthy controls followed for 6 months after adenotonsillectomy.
I
Intervention
Adenotonsillectomy
C
Comparator
Matched healthy non-snoring controls
O
Outcome
Baroreflex sensitivity (BRS) parameters at 6 monthssurrogate

Adenotonsillectomy in children with severe OSAS partially reverses autonomic dysfunction as measured by baroreflex sensitivity, though some impairments may persist at 6 months.

Limitations

  • Data did not have sufficient resolution to discriminate between the effects of oxygen desaturation and arousals
  • Power issues from loss of some subjects to follow-up

Cite This Study

Muzumdar et al. (2012) conducted an editorial in Obstructive sleep apnea syndrome (OSAS). Adenotonsillectomy vs. Matched healthy non-snoring controls was evaluated on Baroreflex sensitivity (BRS) parameters. Adenotonsillectomy in children with severe OSAS increased most baroreflex sensitivity parameters at 6 months, though some indices remained lower than healthy controls.

synapsesocial.com/papers/6aa4dcccf197b883c13d62b0https://doi.org/10.5665/sleep.2094
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