Key result
Pathogenic variants in adolescents with infarct-like myocarditis linked to ~180% higher recurrence risk.
Why the study?
Data on the genetic contribution to pediatric uncomplicated or infarct-like myocarditis remain scarce.
What is the prevalence of pathogenic or likely pathogenic variants in adolescents with infarct-like myocarditis, and how do they associate with clinical and imaging findings?
Population
30 adolescents with infarct-like myocarditis across five hospitals in Catalunya, Spain
Comparison
Genetic-positive vs genetic-negative patients
Design
Prospective multicenter study
Follow-up
Median 3 years (IQR 2-7)
Authors
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P/LP variants occurred in 22% of adolescents with infarct-like myocarditis and linked to recurrence plus persistent CMR changes; leaves open whether routine testing improves outcomes.
Cohort (n=30)
Yes
What is the prevalence of pathogenic or likely pathogenic variants in adolescents with infarct-like myocarditis, and how do they associate with clinical and imaging findings?
Absolute Event Rate: 66.7% vs 23.8%
A high prevalence (22.2%) of pathogenic variants in cardiomyopathy-associated genes was found in adolescents with infarct-like myocarditis, particularly those with ring-like LGE patterns, suggesting a need for genetic testing and long-term monitoring.
Esmel-Vilomara et al. (2025) conducted a cohort in Infarct-like myocarditis (n=30). Pathogenic or likely pathogenic (P/LP) variants vs. No P/LP variants was evaluated on Recurrent myocarditis. Pathogenic or likely pathogenic genetic variants were identified in 22.2% of adolescents with infarct-like myocarditis and were associated with higher rates of recurrence (66.7% vs. 23.8%).
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