Key result
Endogenous 17β-oestradiol is linked to higher plasma fibrinogen in postmenopausal women, especially overweight subjects.
Why the study?
Are endogenous sex steroid hormones associated with plasma fibrinogen levels in postmenopausal women?
Cohort (n=602)
Yes
Are endogenous sex steroid hormones associated with plasma fibrinogen levels in postmenopausal women?
Effect estimate: β = 0.148
p-value: p=<0.001
Endogenous oestradiol is positively and independently correlated with plasma fibrinogen in postmenopausal women, suggesting a potential deleterious effect on cardiovascular risk profile.
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May link endogenous oestradiol to fibrinogen-related cardiovascular risk in postmenopausal women; hypothesis-generating and requires prospective validation.
Canonico et al. (2012) conducted a cohort in Postmenopausal women (n=602). Endogenous 17β-oestradiol (E2) was evaluated on Plasma fibrinogen levels (β = 0.148, p=<0.001). Endogenous 17β-oestradiol was positively associated with plasma fibrinogen levels among postmenopausal women (β = 0.148, P < 0.001), with a stronger association in overweight subjects.
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