What question did this study set out to answer?

To investigate the role of tumour necrosis factor-alpha (TNF-alpha) and its soluble receptors in cardiovascular disease among patients with systemic lupus erythematosus.

June 1, 2003Lupus

TNF-α: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease

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To investigate the role of tumour necrosis factor-alpha (TNF-alpha) and its soluble receptors in cardiovascular disease among patients with systemic lupus erythematosus.
Compared 26 women (mean age 52 +/- 8.2 years) with systemic lupus erythematosus (SLE) and prior cardiovascular disease (CVD) against 26 age-matched SLE controls without CVD and 26 age-matched population controls.
Quantified plasma concentrations of TNF-alpha, soluble TNF receptor 1 (sTNFR1), and soluble TNF receptor 2 (sTNFR2) using ELISA, evaluating correlations with lipids, waist-hip ratio, and insulin resistance.
Circulating TNF-alpha, sTNFR1, and sTNFR2 were significantly higher in SLE cases than in SLE controls (P = 0.009, P = 0.001, and P = 0.001, respectively), with SLE controls showing higher levels than population controls (P = 0.001, P = 0.02, and P = 0.001, respectively).
In the SLE CVD case group, TNF-alpha correlated positively with plasma triglycerides (r = 0.57, P < 0.002), VLDL triglycerides (r = 0.54, P = 0.004), VLDL cholesterol (r = 0.58, P = 0.002), and waist-hip ratio, but not with estimated insulin resistance.

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Implication

Case-control study reveals elevated TNF-alpha and soluble receptors linked to triglycerides in women with lupus and cardiovascular disease, highlighting an inflammatory mechanism.

Cite This Study

Svenungsson et al. (2003) studied this question.

synapsesocial.com/papers/6aa4e6e8997531f890143113 https://doi.org/10.1191/0961203303lu412oa

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Implication

Case-control study reveals elevated TNF-alpha and soluble receptors linked to triglycerides in women with lupus and cardiovascular disease, highlighting an inflammatory mechanism.

TNF-α: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease

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Discussion

Implication

Cite This Study

TNF-α: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease

Key Points

Discussion

Implication

Cite This Study

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