Key result
Roux-en-Y surgery cuts BMI by ~28% at 3 months, improving lipid and oxidative stress markers.
Why the study?
The study was conducted to evaluate inflammatory and biochemical parameters in the serum of patients with obesity before and after bariatric surgery.
Does Roux-en-Y bariatric surgery improve lipid profiles, inflammatory markers, and oxidative stress in patients with grade II or III obesity?
Cohort (n=23)
No
Does Roux-en-Y bariatric surgery improve lipid profiles, inflammatory markers, and oxidative stress in patients with grade II or III obesity?
Absolute Event Rate: 28.94% vs 40.41%
p-value: p=<0.001
Roux-en-Y bariatric surgery significantly improves lipid profiles, systemic inflammation, and oxidative stress in patients with severe obesity as early as 3 months post-procedure.
May support early metabolic monitoring in severe obesity; extends cohort data but leaves open randomized confirmation of outcomes.
Purpose: To evaluate inflammatory and biochemical parameters in the serum of patients with obesity before and after bariatric surgery. Materials and Methods: An epidemiological study of the prospective cohort type was conducted to follow patients classified with grade II or III obesity undergoing bariatric surgery. Body mass index (BMI), lipid profile, C-reactive protein (CRP), reactive oxygen species production using dichlorofluorescein (DCF), and antioxidant defenses superoxide dismutase (SOD) and reduced glutathione (GSH) were analyzed before and 3 months after Roux-en-Y bariatric surgery. Results: A paired analysis was conducted, evaluating 23 patients in the pre- and post-surgical period. A statistically significant reduction was observed after bariatric surgery in BMI (P value<0.001), total cholesterol (CT) (P value=0.0006), total triglycerides (P value=0.0025), high-density lipoprotein cholesterol (P value=0.0010), low-density lipoprotein cholesterol (P value=0.0189), CRP (P value=0.0130), DCF (P value=0.0069), and GSH (P value<0.0001), as well as an increase in SOD activity (P value=0.0005). Conclusion: Bariatric surgery effectively reduced inflammatory and lipid markers and reversed oxidative stress, indicating that the procedure improves the health of bariatric patients across various parameters.
No takes yet. Share an insight, caveat, or question.
Bett et al. (2025) conducted a cohort in Grade II or III obesity (n=23). Roux-en-Y bariatric surgery vs. Pre-surgical baseline was evaluated on Body mass index (BMI) (p=<0.001). Roux-en-Y bariatric surgery significantly reduced body mass index from 40.41 to 28.94 kg/m2 (p<0.001) and improved lipid and oxidative stress markers at 3 months.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: