Key result
Serial CMR reveals transient apical wall thickening in Takotsubo cardiomyopathy is reversible edema, not hypertrophy.
Why the study?
Takotsubo cardiomyopathy can show transient apical wall thickening from myocardial oedema during recovery, causing diagnostic overlap with apical hypertrophic cardiomyopathy.
Case Report (n=1)
Serial cardiac MRI with tissue characterization is important to differentiate reversible myocardial edema in Takotsubo cardiomyopathy from true apical hypertrophic cardiomyopathy.
Transient apical thickening post-Takotsubo may mimic apical HCM due to oedema; leaves open need for serial CMR validation.
Takotsubo cardiomyopathy can exhibit transient apical wall thickening during recovery, leading to a phenotypic overlap with apical hypertrophic cardiomyopathy. This pseudo-hypertrophic appearance is due to reversible myocardial oedema rather than genuine sarcomeric hypertrophy. We present a case demonstrating this diagnostic challenge and emphasising the importance of serial cardiac magnetic resonance imaging with tissue characterisation.
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Elzoghby et al. (2025) conducted a case report in Takotsubo cardiomyopathy (n=1). Takotsubo cardiomyopathy was evaluated. Serial cardiac magnetic resonance imaging demonstrated that transient apical wall thickening in Takotsubo cardiomyopathy is due to reversible myocardial oedema rather than genuine hypertrophy.
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