Key result
Post-mortem CMR using wall thickness standard deviation >2.4 accurately identifies hypertrophic cardiomyopathy.
Why the study?
A method of post-mortem cardiac magnetic resonance was needed to reliably diagnose hypertrophic cardiomyopathy despite myocardial rigor mortis.
Does post-mortem cardiac magnetic resonance using a standard deviation of wall thickness > 2.4 accurately diagnose hypertrophic cardiomyopathy?
Observational (n=139)
Does post-mortem cardiac magnetic resonance using a standard deviation of wall thickness > 2.4 accurately diagnose hypertrophic cardiomyopathy?
Effect estimate: AUC 0.95 (95% CI 0.89-0.98)
Post-mortem cardiac magnetic resonance using a standard deviation of wall thickness >2.4 accurately identifies hypertrophic cardiomyopathy as a cause of sudden death despite rigor mortis.
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PMCMR at 25% diastole may support forensic HCM diagnosis; leaves open prospective validation before any practice change.
Aquaro et al. (2020) conducted an observational in Hypertrophic Cardiomyopathy (n=139). Post-mortem cardiac magnetic resonance (PMCMR) was evaluated on Identification of hypertrophic cardiomyopathy (AUC 0.95, 95% CI 0.89-0.98). Post-mortem cardiac magnetic resonance using a standard deviation of wall thickness > 2.4 accurately identified hypertrophic cardiomyopathy (AUC 0.95; 95% CI 0.89-0.98).
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