Key result
Realistic LVAD simulations identify the ascending aorta as the optimal anastomosis location for flow dynamics.
Why the study?
Does applying a realistic LVAD profile compared to a flat profile affect aortic flow fields and what is the optimal anastomosis location?
Does applying a realistic LVAD profile compared to a flat profile affect aortic flow fields and what is the optimal anastomosis location?
Computational fluid dynamics demonstrate that realistic LVAD outflow profiles are necessary for accurate simulation of aortic hemodynamics, suggesting the ascending aorta is the optimal anastomosis site.
Suggests ascending aorta optimizes LVAD anastomosis hemodynamics; hypothesis-generating pending prospective clinical validation.
Left ventricular assist devices (LVADs) are carefully designed, but the significance of the implantation configuration and interaction with the vasculature is complex and not fully determined. The present study employs computational fluid dynamics to investigate the importance of applying a realistic LVAD profile when evaluating assisted aortic flow fields and subsequently compares a number of potential anastomosis locations in a patient-specific aortic geometry. The outflow profile of the Berlin Heart INCOR® device was provided by Berlin Heart GmbH (Berlin, Germany) and the cannula was attached at a number of locations on the aorta. Simulations were conducted to compare a flat profile against the real LVAD profile. The results illustrate the importance of applying an LVAD profile. It not only affects the magnitude and distribution of oscillatory shear index, but also the distribution of flow to the great arteries. The ascending aorta was identified as the optimal location for the anastomosis.
No takes yet. Share an insight, caveat, or question.
Brown et al. (2011) studied Left ventricular assist device (LVAD) implantation. Realistic LVAD outflow profile (Berlin Heart INCOR) vs. Flat outflow profile was evaluated on Magnitude and distribution of oscillatory shear index and flow to the great arteries. Applying a realistic LVAD profile affected the oscillatory shear index and flow distribution, identifying the ascending aorta as the optimal anastomosis location in computational simulations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: