Key result
Borna disease virus emerges as a potential cause of human neuropsychiatric disorders.
Why the study?
Is Borna disease virus (BDV) associated with the causation of human neuropsychiatric disorders?
Is Borna disease virus (BDV) associated with the causation of human neuropsychiatric disorders?
Establishing a viral causative association for behavioural disorders could lead to a paradigm shift in the treatment and management of neuropsychiatric illnesses.
Hypothesis-generating for BDV in neuropsychiatric disorders; prospective studies needed before any causal or therapeutic inferences.
The biological cause of psychiatric illnesses continues to be under intense scrutiny. Among the various neurotropic viruses, Borna disease virus (BDV) is another virus that preferentially targets the neurons of the limbic system and has been shown to be associated with behavioural abnormalities. Presence of various BDV markers, including viral RNA, in patients with affective and mood disorders have triggered ongoing debate worldwide regarding its aetiopathogenic relationship. This article analyses its current state of knowledge and recent advances in diagnosis in order to prove or refute the association of BDV in causation of human neuropsychiatric disorders. This emerging viral causative association of behavioural disorders, which seems to be inching closer, has implication not only for a paradigm shift in the treatment and management of neuropsychiatric illnesses but also has an important impact on the public health systems.
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Thakur et al. (2009) conducted a review in Neuropsychiatric illnesses. Borna disease virus (BDV) was evaluated. Borna disease virus (BDV) is emerging as a potential causative agent for human neuropsychiatric disorders, which could lead to a paradigm shift in treatment and public health management.
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