Key result
Rat models suggest loss of BDV-specific cellular immunity occurs after cell release from bone marrow.
Population
Rats
Design
Preclinical
Authors
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No direct clinical implications from this rat model; leaves open whether post-bone marrow immune impairment contributes to human viral persistence.
The study demonstrates that the loss of BDV-specific cellular immunity in persistently infected newborn rats occurs after immune cells are released from the bone marrow.
Carbone et al. (1991) studied Borna disease. Borna disease virus (BDV) inoculation was evaluated on Development of Borna disease. In a rat model of persistent Borna disease virus infection, the loss of BDV-specific cellular immunity appeared to occur after the release of cells from the bone marrow.
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