Coupled tracer diffusion of sodium hyaluronate in aqueous drugs solutions

Tracer diffusion coefficients of sodium hyaluronate in 0.005 mol dm −3 aqueous drug solutions were investigated by using Taylor dispersion technique at 298.15 K. The drugs studied were caffeine, isoniazid, sodium sulfamerazine, sodium salicylate, and paracetamol. The positive cross-diffusion coefficient between the supporting drug and tracer polyelectrolyte obtained for all systems, particularly for isoniazid, sodium sulfamerazine, and sodium salicylate, indicate the existence of NaHy–drugs interactions and significant coupled diffusion. These findings suggest that sodium hyaluronate may facilitate drug transport, acting as a carrier in aqueous media.