SARS-CoV-2 Infection and ACE-2 Expression in Children: An Overview

SARS-CoV-2 has marked a new era in the medical field with a wide array of signs and symptoms.The clinical manifestations may vary from simple sore throat to severe multiple organ failure causing death in adults.The severity of the disease was relatively mild in children compared to adults but the preliminary evidence reveals high proportions of asymptomatic infection which contributes to a viral transmission.It still remains ambiguous why children are less severely affected than adults.This literature provides a comprehensive review of epidemiology, vulnerability, pathophysiology, organ-specific systemic manifestations of coronavirus disease-2019 (COVID-19), its clinical course similarities and differences between child and adult with a special focus on the reasons behind the reduced disease severity in children.