Key result
Higher cTnT strongly correlates with lower tissue Doppler Ea wave peak velocity in acute HFpEF.
Why the study?
Is cardiac troponin T associated with impaired left ventricular relaxation in patients with acute decompensated heart failure with preserved systolic function?
Observational (n=44)
Is cardiac troponin T associated with impaired left ventricular relaxation in patients with acute decompensated heart failure with preserved systolic function?
In patients with acute decompensated heart failure with preserved ejection fraction, cardiac troponin T levels are strongly associated with the extent of left ventricular relaxation abnormalities and left ventricular mass.
Answers are grounded in this paper and cite their sources.
May flag myocyte injury tied to diastolic impairment in acute HFpEF; hypothesis-generating, needs prospective outcome studies.
AIMS: To examine relationships between cardiac troponin T (cTnT) and parameters of left ventricular (LV) structure and function in patients with acute destabilized heart failure (HF) with preserved LV ejection fraction. METHODS AND RESULTS: In 44 patients with acute heart failure (HF) with preserved left ventricular (LV) ejection fraction, parameters of LV structure and function were assessed via comprehensive two-dimensional Doppler echocardiography. There was no correlation between cTnT and LV wall thickness, left atrial volume index, or transmitral E wave velocity or deceleration time. There were associations between cTnT and LV end-diastolic dimension (r = -0.34, P = 0.02) and LV mass index (r = 0.32; P = .04). A lower tissue Doppler Ea wave peak velocity was associated with higher cTnT concentrations (r = -0.90, P < 0.001). In multivariate analyses, only LV end-diastolic dimension (t = 2.2; P = 0.04), LV mass index (t = 2.3; P = .03), and tissue Doppler Ea wave peak velocity (t = -4.7; P < .001) emerged as significant predictors of cTnT. CONCLUSION: In patients with HF with preserved LV ejection fraction, cTnT is strongly associated with the extent of LV relaxation abnormalities and LV mass.
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Shah et al. (2009) conducted an observational in Acute decompensated heart failure with preserved systolic function (n=44). Cardiac troponin T (cTnT) was evaluated on Correlation between cTnT and tissue Doppler Ea wave peak velocity (r = -0.90, p=<0.001). Higher cardiac troponin T concentrations were strongly associated with lower tissue Doppler Ea wave peak velocity (r = -0.90, P < 0.001) in patients with acute heart failure and preserved EF.
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