Key result
Atropine and propranolol blockade in lambs reveals an intrinsic heart rate of ~185 bpm.
Why the study?
How does the sympathetic and parasympathetic control of basal heart rate develop in unanesthetized fetal and newborn lambs?
How does the sympathetic and parasympathetic control of basal heart rate develop in unanesthetized fetal and newborn lambs?
Changes in basal heart rate during fetal and newborn development in lambs result from a shifting balance between sympathetic and parasympathetic autonomic outflow.
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No immediate change to fetal HR assessment; leaves open translation of lamb autonomic findings to human neonates.
Walker et al. (2009) studied Development of autonomic nervous control of basal heart rate. Atropine and/or propranolol blockade was evaluated on Basal heart rate and autonomic control. Atropine and/or propranolol blockade in fetal and newborn lambs revealed an intrinsic heart rate of about 185 beats/min, with changes in basal heart rate resulting from varying autonomic balance.
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