Key result
Adjunctive pharmacotherapy cuts early post-stenting ischemic events while drug-coated stents show promise for preventing restenosis.
Adjunctive pharmacotherapy with anticoagulants and antiplatelets significantly reduces early ischemic events post-stenting, while drug-eluting stents offer a promising solution for late restenosis.
May guide post-stenting antithrombotic choices; leaves open randomized confirmation for drug-coated stent benefits.
The use of coronary stents improves the outcomes of percutaneous coronary intervention (PCI). This has led to a rapid increase in their use. Coronary stenting is not without problems and is complicated by both early ischemic events and late restenosis. The combination of anticoagulation with unfractionated heparin (UFH) and the use of antiplatelet agents including aspirin, thienopyridines, and glycoprotein IIb/IIIa inhibitors has led to a major reduction in early ischemic events after stenting. Low molecular weight heparin (LMWH) and direct thrombin inhibitors have a number of theoretical advantages over UFH. Their role as an adjunct to coronary stenting is still under investigation. Trials of systemic pharmacotherapy aimed at reducing in-stent restenosis have been consistently disappointing. Preliminary results of stents coated with agents that inhibit neointimal proliferation are extremely promising. The results of ongoing phase III trials of these coated stents are eagerly awaited.
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Harding et al. (2001) conducted a review in Percutaneous coronary intervention (PCI) / Coronary stenting. Adjunctive pharmacotherapy (anticoagulants, antiplatelets, coated stents) was evaluated. Adjunctive pharmacotherapy, including anticoagulation and antiplatelet agents, reduces early ischemic events after coronary stenting, while drug-coated stents show promise for preventing restenosis.
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