Key result
Elevated troponin I at thrombotic microangiopathy presentation predicts ~14-fold greater subsequent AMI risk.
Population
74 consecutive patients with 78 episodes of thrombotic microangiopathies, defined as platelets below 150 x…
Design
Cohort
Authors
Loading...
Elevated troponin I at TMA presentation may identify high early AMI risk; observational data leave open prospective validation before guiding care.
Cohort (n=74)
Relative Risk: 13.5 (95% CI 2.6–86.8)
Acute myocardial infarction is a frequent and severe early complication of thrombotic microangiopathies, particularly in TTP, and can be strongly predicted by elevated LDH and troponin I at presentation.
Patschan et al. (2006) conducted a cohort in Thrombotic microangiopathies (n=74). Serum troponin I > 0.20 ng/ml at TMA presentation vs. Serum troponin I ≤ 0.20 ng/ml was evaluated on Subsequent acute myocardial infarction (AMI) (RR 13.5, 95% CI 2.6-86.8). Serum troponin I > 0.20 ng/ml at presentation of thrombotic microangiopathy strongly predicted subsequent acute myocardial infarction (RR 13.5; 95% CI 2.6-86.8).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: