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A simple and atom‐economic procedure for the selective C‐4 arylation of 2,5‐disubstituted furans via CH bond activation using electron‐deficient aryl bromides is reported. Only 0.5 mol% of the commercially available dimeric (allene)palladium chloride, [Pd(C3H5)Cl]2, was employed as catalyst. This environmentally attractive procedure has been found to be tolerant to a variety of functional groups on the aryl bromide such as carbonyl, nitrile, nitro, fluoro, ester or trifluoromethyl.
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Gottumukkala et al. (2008) studied this question.
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