The Original Haernorrhagic Fever: Yellow Fever

Summary. Monkeys infected with the Asibi strain of yellow fever virus developed multiple coagulation abnormalities 3–4 days after viral inoculation. These coagulation abnormalities occurred almost simultaneoulsy with the development of fever, clinical illness and pathologic changes in the liver. The haemorrhagic manifestation of yellow fever and the rapid development of multiple coagulation abnormalities cannot be explained solely by impaired production of coagulation proteins and suggested that there was accelerated intravascular coagulation. Heparin therapy in one group of infected animals decreased the severity of coagulation abnormalities but did not prolong the life of these animals.