Key result
Crural DVT frequently seeds fatal PTE via secondary free-floating thrombi in ilio-femoral veins.
Highlights the histopathological importance of lower leg DVT, particularly soleal vein thrombi and femoral free-floating thrombi, in fatal pulmonary thromboembolism, emphasizing primary prevention over treatment of established DVT.
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Supports emphasis on soleal vein thrombi for PE prevention; leaves open prospective validation in clinical cohorts.
Ro et al. (2004) conducted a review in Deep vein thrombosis resulting in fatal pulmonary thromboembolism. Deep vein thrombosis was evaluated. Crural type deep vein thrombosis, particularly in the soleal vein, is a frequent primary site for fatal pulmonary thromboembolism, with large emboli forming as secondary free-float thrombi in ilio-femoral veins.
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