Key result
Cudrania tricuspidata extract lowers weight, fat mass, and metabolic markers in high-fat diet-fed mice.
Why the study?
Nonalcoholic fatty liver disease is emerging as a leading cause of life-threatening liver diseases without a specific therapeutic target, though Cudrania tricuspidata has shown metabolic benefits in obesity and diabetes.
Does Cudrania tricuspidata extract improve high-fat diet-induced nonalcoholic fatty liver disease in C57BL/6J mice?
Does Cudrania tricuspidata extract improve high-fat diet-induced nonalcoholic fatty liver disease in C57BL/6J mice?
Cudrania tricuspidata extract alleviates hepatic steatosis in high-fat diet-fed mice by reducing oxidative stress and inflammation via the Nrf-2/HO-1 pathway.
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Hypothesis-generating for Cudrania tricuspidata in murine NAFLD; human trials needed before any clinical consideration.
Shrestha et al. (2021) studied Nonalcoholic fatty liver disease. Cudrania tricuspidata extract vs. High-fat diet alone was evaluated on Body weight, fat mass, hepatic mass, serum glucose level, and liver cholesterol levels. Cudrania tricuspidata extract significantly reduced body weight, fat mass, hepatic mass, serum glucose, and liver cholesterol levels in high-fat diet-fed mice.
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