Key result
Major HDL protein ApoA-I drives cardioprotection by promoting macrophage cholesterol efflux and retarding atherosclerosis.
Design
Review
Authors
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Supports ApoA-I–targeted therapies in development; leaves open whether mimetics reduce events in trials.
ApoA-I plays a key role in HDL's cardioprotective activities by promoting cholesterol efflux from macrophages.
Jay W. Heinecke (2013) conducted a review in Cardiovascular disease. High-density lipoprotein (HDL) and apolipoprotein A-I was evaluated. Apolipoprotein A-I, the major protein in HDL, plays a key role in cardioprotection by promoting cholesterol efflux from macrophages and retarding atherosclerosis.
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