A strong, cooperative O−H···O hydrogen bond network directs isostructurality in pyrazine tetracarboxylic acid, pyridine tetracarboxylic acid, and pyromellitic acid dihydrates. H 2 O and COOH groups reorganize their H bonding groups in an invariant network leading to O w −H···N ⇔ C−H···O w mimicry. The degree of similarity is related to the size of the multicenter synthon and the strength of the O acid −H···O water hydrogen bond.
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Babu et al. (2006) studied this question.
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