Key result
Wood 46 S. aureus induces 100% local infection and antibody response in rabbits versus Cowan I.
Absolute Event Rate: 100% vs 0%
In an experimental rabbit model of osteomyelitis, infection with an alpha-toxin-producing strain of S. aureus elicited a strong but transient precipitating antibody response compared to an alpha-toxin negative strain.
Alpha-toxin-producing S. aureus strains elicit stronger antibody responses in rabbit osteomyelitis; hypothesis-generating for strain-specific human infection outcomes.
Eight rabbits were infected with Staphylococcus aureus by injection of 1 X 10(8) colony-forming units into the marrow cavity of the tibia. Titres of precipitating antibodies against S. aureus in serum were followed by means of crossed immunoelectrophoresis. Four rabbits infected with the protein A-containing, alpha-toxin negative Cowan I strain developed no signs of infection and only a slight or no antibody response. All 4 rabbits infected with the protein A-free, alpha-toxin-producing Wood 46 strain developed local signs of infection, and 3 of 4 developed roentgenologic signs of osteomyelitis. All 4 rabbits developed a very high level of precipitating antibodies, but after 2-3 months the level of antibodies decreased, although the infection continued.
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Espersen et al. (1982) studied Experimental osteomyelitis (n=8). Infection with protein A-free, alpha-toxin-producing Wood 46 strain of S. aureus vs. Infection with protein A-containing, alpha-toxin negative Cowan I strain was evaluated on Development of local signs of infection and precipitating antibodies. Rabbits infected with the Wood 46 strain of S. aureus developed local signs of infection and high levels of precipitating antibodies (100%), whereas those infected with the Cowan I strain did not.
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