Key result
Negative-pressure wound therapy and latissimus dorsi flap repair massive chest wall defect after epirubicin extravasation.
Case Report (n=1)
Negative-pressure wound therapy combined with a latissimus pedicle flap is a viable strategy for chest wall reconstruction following epirubicin extravasation.
May offer reconstructive strategy for epirubicin-induced chest wall defects; single case leaves open reproducibility and safety.
PURPOSE: Accidental extravasation is a serious iatrogenic injury among patients receiving anthracycline-containing chemotherapy. The aim of this work is to present a combination therapy for chest wall reconstruction following epirubicin extravasation. METHODS: Herein, we report a 68-year-old woman with massive soft tissue necrosis of the anterolateral chest wall after epirubicin extravasation from a port implanted in the subclavicular area. RESULTS: The necrotic tissue was resected, the port was removed, and negative-pressure wound therapy was applied. Three weeks later, a latissimus dorsi pedicle flap was successfully used to cover the defect. CONCLUSIONS: To the best of the authors' knowledge, this is the first report of a strategy comprising the combination of negative-pressure wound therapy and a latissimus pedicle flap for reconstruction of the chest wall after soft tissue necrosis following epirubicin extravasation.
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Papadakis et al. (2017) conducted a case report in Epirubicin extravasation with massive soft tissue necrosis (n=1). Negative-pressure wound therapy and latissimus dorsi pedicle flap was evaluated on Defect coverage and chest wall reconstruction. Negative-pressure wound therapy combined with a latissimus dorsi pedicle flap successfully reconstructed a massive chest wall defect following epirubicin extravasation.
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