Key result
Calcium regulates renal antidiuretic hormone-stimulated adenylate cyclase and inhibits binding at millimolar concentrations.
Calcium plays multiple regulatory roles in the antidiuretic hormone-stimulated adenylate cyclase system in porcine renal plasma membranes, inhibiting both hormone binding and enzyme activity at different concentrations.
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Does not yet alter management of water balance disorders; leaves open calcium's role in human ADH signaling in vivo.
Woodward et al. (1972) studied this question. Antidiuretic hormone and calcium was evaluated on Adenylate cyclase activity and hormone binding. Calcium plays multiple regulatory roles in antidiuretic hormone-stimulated adenylate cyclase activity in porcine renal plasma membranes, inhibiting binding at millimolar concentrations.
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