Key result
COVID-19 mRNA vaccines linked to CV side effects, primarily myocarditis, though causality remains hypothetical.
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Why the study?
Although studies have linked COVID-19 mRNA vaccines to cardiovascular complications like myocarditis, causality and the underlying pathogenesis remain hypothetical.
What are the cardiovascular side effects and associated pathophysiology of COVID-19 mRNA vaccines?
What are the cardiovascular side effects and associated pathophysiology of COVID-19 mRNA vaccines?
This review summarizes the epidemiology, clinical ramifications, and cellular pathogenesis of adverse cardiovascular outcomes, particularly myocarditis, following COVID-19 mRNA vaccination.
May warrant clinical vigilance for myocarditis post-mRNA vaccination; leaves open causality and pathogenesis for prospective investigation.
The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology.
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Almas et al. (2022) conducted a review in COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes. COVID-19 mRNA vaccines was evaluated on Cardiovascular side effects and associated pathophysiology. COVID-19 mRNA vaccines are associated with adverse cardiovascular side effects, most commonly myocarditis, though causality and underlying pathogenesis remain hypothetical.
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