Key result
Non-thermal millimeter microwaves greatly modify the Hill coefficient and apparent affinity of Ca2+-activated K+ channels.
Non-thermal microwave exposure alters the cooperativity and binding characteristics of Ca2+-activated K+ channels in cultured kidney cells.
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Non-thermal mm-wave exposure effects on renal K+ channels remain unproven in vivo; leaves open relevance to human physiology or safety limits.
Using the patch voltage-clamp method, possible effects of millimetre microwaves (42.25 GHz) on single Ca(2+)-activated K+ channels in cultured kidney cells (Vero) were investigated. It was found that exposure to the field of non-thermal power (about 100 microW/cm2) for 20-30 min greatly modifies both the Hill coefficient and an apparent affinity of the channels for Ca2+(i). The data suggest that the field alters both cooperativity and binding characteristics of the channel activation by internal Ca2+. The effects depend on initial sensitivity of the channels to Ca2+ and the Ca2+ concentration applied.
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Geletyuk et al. (1995) studied Cultured kidney cells (Vero). Millimetre microwaves (42.25 GHz) was evaluated on Hill coefficient and apparent affinity of the channels for Ca2+(i). Exposure to millimetre microwaves (42.25 GHz) at non-thermal power for 20-30 min greatly modifies both the Hill coefficient and apparent affinity of single Ca2+-activated K+ channels for internal Ca2+.
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