Why the study?
Does increasing temperature and intracellular calcium affect the activation rate and maximal conductance of minK channels expressed in Xenopus oocytes?
Population
Xenopus oocytes expressing slowly activating, voltage-dependent minK channels cloned from rat kidney
Comparison
Increase in bath temperature and increase in… vs Baseline temperature and baseline [Ca2+]i
Design
Preclinical
Authors
Loading...
MinK temperature and Ca2+ effects in oocytes mirror guinea pig IKs; hypothesis-generating for cardiac repolarization with no clinical implications yet.
Does increasing temperature and intracellular calcium affect the activation rate and maximal conductance of minK channels expressed in Xenopus oocytes?
The interaction of intracellular calcium and temperature on minK channel activation in Xenopus oocytes closely resembles effects on the slowly activating potassium conductance IKs in guinea pig cardiac myocytes.
Büsch et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: