Identification of a novel 130-amino acid membrane protein that induces a slow voltage-gated potassium current, distinct from previously known ion channel proteins.
No immediate clinical implications; extends molecular diversity of voltage-gated K+ channels in animal models.
A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.
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Takumi et al. (1988) studied this question.
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