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March 21, 1994FEBS Letters

Molecular cloning, functional expression and localization of a novel inward rectifier potassium channel in the rat brain

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Population

Mouse brain cDNA library and Xenopus oocytes

Design

Preclinical

Authors

HKHidekazu KoyamaNippon Veterinary and Life Science UniversityKMKen‐ichirou MorishigeOsaka Prefectural Medical Center
Naohiko Takahashi
Naohiko TakahashiElectrophysiology

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Overview

Does not alter clinical practice; extends molecular tools for neuronal K+ channels and leaves open their roles in brain excitability.

Structured PICO

P
Population
Mouse brain cDNA library and Xenopus oocytes
I
Intervention
Molecular cloning and functional expression of IRK1
O
Outcome
Functional expression and localization of the inward rectifier potassium channel

This study provides the first demonstration of the cloning and distribution of an inward rectifier potassium channel from the nervous system.

Cite This Study

Koyama et al. (1994) studied this question.

synapsesocial.com/papers/6a7ea87eb2811efa75cda1d2https://doi.org/10.1016/0014-5793(94)80478-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Voltage‐dependent activation of the inward‐rectifier potassium channel in the ventricular cell membrane of guinea‐pig heart.1985 · 200 citations
  2. 2The Mg2+ block and intrinsic gating underlying inward rectification of the K+ current in guinea‐pig cardiac myocytes.1989 · 158 citations
  3. 3Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish.1976 · 471 citations
  4. 4A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects1993 · 544 citations
  5. 5Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain1993 · 63 citations