Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.
Population
Mouse brain cDNA library and Xenopus oocytes
Comparison
Expression of MB-IRK2 cRNA vs MB-IRK1 current
Design
Preclinical
Authors
Discussion
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Overview
Distinguishes a novel Kir isoform in vitro; leaves open its role in human cardiac or neuronal excitability.
Structured PICO
P
Population
Mouse brain cDNA library and Xenopus oocytes
I
Intervention
Expression of MB-IRK2 cRNA
C
Comparator
MB-IRK1 current
O
Outcome
K+ current characteristics (inward rectifying properties, inactivation, single channel conductance, steady-state open probability)surrogate
Identifies and characterizes a novel inward rectifier potassium channel (MB-IRK2) with distinct electrophysiological properties and tissue distribution compared to MB-IRK1.
Cite This Study
Takahashi et al. (1994) studied this question.