Molecular cloning and functional expression of a novel brain‐specific inward rectifier potassium channel
Population
Mouse brain cDNA library and Xenopus oocytes
Comparison
Cloning and functional expression of MB-IRK3 vs MB-IRK1, RB-IRK2, ROMK1, and GIRK1
Design
Preclinical
Authors
Discussion
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Member takes
Overview
No immediate clinical implications; extends the molecular diversity of forebrain Kir channels for functional studies.
Structured PICO
P
Population
Mouse brain cDNA library and Xenopus oocytes
I
Intervention
Cloning and functional expression of MB-IRK3
C
Comparator
MB-IRK1, RB-IRK2, ROMK1, and GIRK1
O
Outcome
Electrophysiological properties and mRNA expression localization
The cloning of MB-IRK3 reveals a novel brain-specific inward rectifier potassium channel with distinct electrophysiological properties and forebrain localization.
Cite This Study
Morishige et al. (1994) studied this question.