Rat brain cDNA RCK1 encodes a functional potassium channel with delayed rectifier properties when expressed in Xenopus oocytes.
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Enables biophysical studies of cloned K+ channels in oocytes; leaves open native roles in mammalian neurons and heart.
Injection into Xenopus oocytes of RNA synthesized in vitro using the rat brain cDNA RCK1 as a template or nuclear injection of the cDNA results in the expression of functional potassium channels. These channels exhibit properties similar to those of the non-inactivating delayed rectifier channel found in mammalian neurons and other excitable cells.
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Stühmer et al. (1988) studied this question.
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