Key result
Rat1 sodium channels exhibited a slower time course of fast inactivation than Rat2, but recovered from fast inactivation more rapidly, consistent with a role in mediating transient currents.
Population
Xenopus oocytes injected with RNA encoding Rat1 and Rat2 sodium channels
Comparison
Expression of Rat1 sodium channels vs Expression of Rat2 sodium channels
Design
Preclinical
Authors
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Isoform kinetics may shape neuronal signaling; leaves open relevance to mammalian circuits or human disease.
Rat1 sodium channels exhibit distinct electrophysiological properties compared to Rat2, consistent with a role in mediating rapidly inactivating, transient currents in Purkinje cells.
Smith et al. (1998) studied this question. Rat1 sodium channel expression vs. Rat2 sodium channel expression was evaluated on Electrophysiological properties (inactivation kinetics and recovery). Rat1 sodium channels exhibited a slower time course of fast inactivation than Rat2, but recovered from fast inactivation more rapidly, consistent with a role in mediating transient currents.
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