May 1, 1992The Journal of PhysiologyOpen Access

Regulation by second messengers of the slowly activating, voltage‐dependent potassium current expressed in Xenopus oocytes.

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Population

Xenopus oocytes injected with RNA transcribed in vitro from a cloned complementary DNA

Design

Preclinical

Authors

ABAndreas BüschClaremont McKenna College MKMichael P. KavanaughBrigham and Women's Hospital MVMichael D. VarnumWashington State University

Discussion

Member takes

Implication

No immediate clinical implications; leaves open relevance of this dual regulation to native mammalian cardiac electrophysiology.

Structured PICO

Population

Xenopus oocytes injected with RNA transcribed in vitro from a cloned complementary DNA (and some with RNA encoding the 5-HT2 receptor)

Intervention

Application of second messengers and modulators (calcium ionophore A23187, IP3, BAPTA, phorbol esters, staurosporine, 5-HT, caffeine)

Outcome

Slowly activating, voltage-dependent potassium currentsurrogate

The slowly activating, voltage-dependent potassium current is dually regulated by intracellular calcium (which increases the current) and protein kinase C (which decreases the current).

Cite This Study

Büsch et al. (1992) studied this question.

synapsesocial.com/papers/6a7e1403fc4f0e65bd3bfa80 https://doi.org/10.1113/jphysiol.1992.sp019138

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