A novel c.145C>G variation in ABO*B.01 allele is associated with a B 3 phenotype

Q: What does this research mean for the field?

A novel c.145C>G variation in the ABO*B.01 allele is associated with the B3 blood group phenotype. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Y. Li; HAN Wei; Wenwen Kou; Zhaoze Ma; Hongmei Yang; Liling Zhou; Chen-Long Wang

doi:10.1111/trf.70387

September 10, 2026Transfusion

A novel c.145C>G variation in ABO*B.01 allele is associated with a B 3 phenotype

View at Publisher

Ask AI

Bookmark

Share

Key Points

To identify and characterize the genetic variation responsible for an atypical weak B3 blood group phenotype.
Performed serological typing to evaluate red blood cell surface antigen expression and agglutination patterns.
Conducted targeted DNA sequencing and molecular genotyping of the ABO gene.
Identified a novel c.145C>G single nucleotide variation localized to the ABO*B.01 allele.
Demonstrated that the c.145C>G substitution correlates with the characteristic weakened antigen expression of the B3 phenotype.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Genetic analysis reveals a novel c.145C>G mutation in the ABO*B.01 allele, indicating a molecular mechanism underlying the weak B3 blood phenotype.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6aa51ef5327956e4761f8f1b https://doi.org/10.1111/trf.70387

View at Publisher

Ask AI

Bookmark

Share

A novel c.145C>G variation in ABO*B.01 allele is associated with a B 3 phenotype

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

A novel c.145C>G variation in ABO*B.01 allele is associated with a B 3 phenotype

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading