Key result
STEMI features ~43% higher admission MMP-9 levels versus NSTEACS, linked to the -1562C>T polymorphism.
Why the study?
Is the MMP-9 (-1562C>T) polymorphism associated with higher serum MMP-9 levels in patients with STEMI compared to NSTEACS?
Cross-Sectional (n=70)
No
Is the MMP-9 (-1562C>T) polymorphism associated with higher serum MMP-9 levels in patients with STEMI compared to NSTEACS?
High serum MMP-9 levels are independently associated with STEMI, and the MMP-9 (-1562C>T) polymorphism may contribute to this elevation during acute plaque rupture.
May aid STEMI differentiation from NSTEACS; leaves open whether the MMP-9 polymorphism drives plaque rupture.
BACKGROUND: Matrix metalloproteinase (MMP)-9 is excessively expressed in frail region of atherosclerotic plaque and released in circulation following plaque rupture. High MMP-9 level associated with severity of occluded thrombus and subsequent myocardial infarction. MMP-9 (-1562C>T) polymorphism associated with acute myocardial infarction, however conflicting data present regarding impact of MMP-9 (-1562C>T) polymorphism on circulating MMP-9 level in acute myocardial infarction with ST-elevation (STEMI), clinical entity represents totally occluded coronary thrombus. METHODS: We enrolled consecutively subjects with acute coronary syndrome treated in intensive coronary care unit. Acute coronary syndrome diagnosis were classified into STEMI and non-ST-elevation acute coronary syndrome (NSTEACS). Seventy consecutive subjects were enrolled for this study, 31 subjects with STEMI and 39 subjects with NSTEACS. RESULTS: On admission serum MMP-9 level, measured with sandwich enzyme immunoassay, were higher in STEMI as compared with NSTEACS (1,574.2 ± 604.1 ng/mL vs. 1,104.4 ± 591.5 ng/mL, P < 0.01). Proportion of subjects with MMP-9 (-1562C>T) polymorphism, analyzed with PCR-RFLP, were higher in STEMI as compared with NSTEACS (66.7% vs. 33.3%, P = 0.15). T allele frequency was almost twice in STEMI as compared to in NSTEACS. Almost all (83%) subjects with MMP-9 (-1562C>T) polymorphism had high serum MMP-9 level (> 1,334.5 ng/mL) during STEMI, whereas in NSTEACS all subjects had low level. CONCLUSION: MMP-9 (-1562C>T) polymorphism associated with high serum MMP-9 level in patients with STEMI.
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Budi Y Setianto (2012) conducted a cross-sectional in Acute Coronary Syndrome (n=70). ST-elevation acute myocardial infarction (STEMI) vs. Non-ST-elevation acute coronary syndrome (NSTEACS) was evaluated on Serum MMP-9 level on admission (p=0.005). Patients with STEMI had significantly higher serum MMP-9 levels on admission compared to patients with NSTEACS (1,574.2 vs 1,104.4 ng/mL), and the MMP-9 (-1562C>T) polymorphism was associated with high MMP-9 levels in STEMI.
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