Key result
Sertraline withdrawal linked to orthostatic hypotension and dizziness manageable by extended titration.
Why the study?
Does sertraline withdrawal cause orthostatic hypotension in a patient treated for depression?
Case Report (n=1)
Does sertraline withdrawal cause orthostatic hypotension in a patient treated for depression?
Sertraline withdrawal can induce orthostatic hypotension, which may require an extended titration period to discontinue successfully.
Sertraline withdrawal may induce orthostatic hypotension; single case leaves open need for extended titration protocols.
Sertraline is a member of the newest class of antidepressants, the selective serotonin reuptake inhibitors. Due to its inherent selectivity and its lack of action with norepinephrine, dopamine, monoamine oxidase, and cholinergic receptors, this drug is unlikely to have any cardiovascular activity. A patient receiving sertraline for depression developed dizziness and orthostatic hypotension on repeated attempts to discontinue the drug. All other organic factors were ruled out. The hypotension was proved to be secondary to sertraline by repeated rechallenges. After a variety of attempted treatments, the agent was discontinued successfully through an extended titration period. This report should guide clinicians in treating patients with a similar problem.
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Amsden et al. (1996) conducted a case report in Depression (n=1). Sertraline withdrawal was evaluated on Orthostatic hypotension and dizziness. Sertraline withdrawal induced dizziness and orthostatic hypotension in a patient treated for depression, which was successfully managed through an extended titration period.
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