Antimicrobial Efficiency of a Marine Streptomyces sp. VPTSA1-4 Isolated from Coromandel Coast of Bay of Bengal, India

Background and Objective:The need and search for therapeutic agents in the treatment of existing and emerging microbial diseases have intensified.The ever-reliable marine streptomycetes have been less explored for such antimicrobial agents and the present study is an attempt in that direction, wherein actinobacteria from marine sources are assessed for their antimicrobial activity. Materials and Methods:The actinobacteria isolated from coastal soils were screened for antimicrobial activity against microbial pathogens.Streptomycetes with the best activity were identified by 16S rRNA gene sequencing.The bioactive compound was extracted and subjected to spectral studies.Mean values of the data derived in antimicrobial efficacy were statistically analyzed.Results: Out of 19 isolates, Streptomyces sp., VPTSA1-4 exhibited the best antimicrobial activity and hence, 16S rRNA genome was sequenced to ascertain the identity of the isolate produced maximum antimicrobial compound at 30EC on the 9th day with a pH of 8 and salinity of 4%, on a starch-casein medium.Further, the potential isolate was identified as Streptomyces tuirus VPTSA1.Conclusion: The study suggested that antimicrobial compounds from Streptomyces tuirus could be used as alternative antimicrobial drugs to drug-resistant pathogens.