Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes
Key result
Obesity, not impaired fasting glucose, is linked to ~40% greater odds of high CAC in non-diabetics.
- OR 1.4
- 95% CI 1.1-1.7
- P=0.005
- n=3,054
Why the study?
Are impaired fasting glucose and obesity independently associated with high coronary artery calcification in adults without diabetes or known vascular disease?
Population
3,054 community-based adults free from known vascular disease or diabetes, mean age 50 years, 49% women, 29%…
Comparison
Impaired fasting glucose and obesity vs Normal fasting glucose and non-obese individuals
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Obesity may inform CAC risk assessment in nondiabetics without diabetes; leaves open impaired fasting glucose contribution and requires prospective confirmation.
Study Design
Type
Cohort (n=3,054)
Structured PICO
Are impaired fasting glucose and obesity independently associated with high coronary artery calcification in adults without diabetes or known vascular disease?
P
Population
3,054 community-based adults (mean age 50 years, 49% women) free from known vascular disease or diabetes.
E
Exposure
Impaired fasting glucose (5.6-6.9 mmol/L) and obesity (BMI ≥30 kg/m²)
C
Comparator
Normal fasting glucose and non-obese individuals
O
Outcome
High coronary artery calcification (CAC) defined as >90th percentile for age and sex, assessed by multidetector computed tomographysurrogate
Main Result
Odds Ratio: 1.4 (95% CI 1.1–1.7)
p-value: p=0.005
In a community-based cohort without diabetes, obesity but not impaired fasting glucose was independently associated with high coronary artery calcification, highlighting the importance of obesity in early atherosclerosis.
Cite This Study
Rutter et al. (2012) conducted a cohort in Without diabetes or known vascular disease (n=3,054). Obesity (BMI ≥30 kg/m2) vs. Non-obese was evaluated on High coronary artery calcification (>90th percentile for age and sex) (OR 1.4, 95% CI 1.1-1.7, p=0.005). In adults without diabetes, obesity was independently associated with high coronary artery calcification (OR 1.4; 95% CI 1.1-1.7; P=0.005), whereas impaired fasting glucose was not.