Key result
High-frequency ultrasound establishes normal carotid intima media thickness percentiles for a Pakistani cohort.
Why the study?
What are the normal carotid intima media thickness percentile values for a Pakistani population?
Cross-Sectional (n=257)
No
What are the normal carotid intima media thickness percentile values for a Pakistani population?
This study establishes population-specific carotid intima media thickness percentile graphs for a Pakistani cohort to aid in assessing vascular health.
Provides CIMT percentiles for Pakistanis; extends ethnicity-specific references but leaves open prognostic validation before clinical adoption.
Carotid artery intima media thickness estimation is a well-established way of cardio vascular disease evaluation. The purpose of this cross-sectional study was to develop normal carotid intima media thickness percentile values for a Pakistani cohort. Data was collected at the Departments of Radiology and Family Medicine, The Aga Khan University Hospital, Karachi, from April 2014 to August 2015. High frequency ultrasound of carotid was done in 257 patients [97 male (38%), 160 female (62%)] without any known carotid artery disease. Reference ranges (90% range between 5th and 95th centiles) were constructed for each common carotid and internal carotid artery measurement and displayed in graph form. The mean difference was found in left common carotid artery (0.55 ±0.13) and left internal carotid artery thickness (0.50 ±0.10) significant at p=0.031 and p=0.014, respectively. The IMTpercentile graphs developed in this study for internal and common carotid arteries are exclusive for this population and can be used to assess vascular health from ultrasound measurements.
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Mirza et al. (2017) conducted a cross-sectional in Without known carotid artery disease (n=257). Carotid intima media thickness measurement was evaluated on Normal carotid intima media thickness percentile values (5th to 95th centiles). Carotid intima media thickness percentiles were established for a Pakistani cohort, with significant mean differences found in the left common (0.55 ±0.13, p=0.031) and internal carotid arteries.
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