Key result
VTE within 6 months before cancer diagnosis linked to ~148% higher mortality risk.
Cohort (n=304,036)
Hazard Ratio: 2.48 (95% CI 2.38–2.58)
Absolute Event Rate: 19% vs 54%
p-value: p=<0.001
Recent pre-cancer VTE may flag patients for intensified surveillance; leaves open whether it is causal or a marker of aggressive disease.
METHODS: We carried out a retrospective study of prognosis in Scottish patients diagnosed with cancer within 5 years after a venous thromboembolism (VTE). RESULTS AND CONCLUSIONS: Prognosis was significantly poorer if a VTE occurred up to 2 years before cancer diagnosis, most notably if the cancer was diagnosed in the 6 months after a VTE.
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Jones et al. (2009) conducted a cohort in Malignancy (n=304,036). Venous thromboembolism (VTE) vs. No VTE in the 5 years before malignancy was evaluated on Death from any cause (HR 2.48, 95% CI 2.38-2.58, p=<0.001). A diagnosis of venous thromboembolism within 6 months prior to a cancer diagnosis was associated with a significantly poorer prognosis, with a hazard ratio for death of 2.48.
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