Synthesis of Deuterated Mevalonolactone Isotopomers

A synthetic route was developed for the preparation of deuterated mevalonolactones. Using low‐cost deuterated reagents, this route allows for the independent introduction of deuterium labeling into any carbon position or into any combination of positions. Following this approach, the synthesis of [6,6,6‐2H3]mevalonolactone, [4,4,6,6,6‐2H5]mevalonolactone, [5,5‐2H2]mevalonolactone, [5,5,6,6,6‐2H5]mevalonolactone, and [2,2,6,6,6‐2H5]mevalonolactone is described.