Key result
Immunohistochemical staining revealed positive expression of proliferating cell nuclear antigen (PCNA) in the epithelial cells of the cortical lesion in a patient with AIMAH.
Case Report (n=1)
PCNA is expressed in the epithelial cells of cortical lesions in AIMAH, suggesting a specific factor for adrenal cortical cell growth may be involved.
ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH) has been recently described as a rare cause of Cushing's syndrome and it is an unusual process of unknown etiology. This report describes a case of a 59-year-old man with AIMAH. The proliferating cell nuclear antigen (PCNA) has been implicated in the process of cell proliferation and is detectable throughout most of the cell cycle. This report also describes the expression of PCNA in AIMAH by immunohistochemical staining. Most of the positive expression was seen in the greater part of the epithelial cells of the cortical lesion, but not in the interstitial cells. These data suggest that some effective factor, specific for adrenal cortical cell growth, might be produced in AIMAH.
No takes yet. Share an insight, caveat, or question.
Nomata et al. (1995) conducted a case report in ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH) (n=1). Immunohistochemical staining for proliferating cell nuclear antigen (PCNA) was evaluated on Expression of PCNA in AIMAH. Immunohistochemical staining revealed positive expression of proliferating cell nuclear antigen (PCNA) in the epithelial cells of the cortical lesion in a patient with AIMAH.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: