Synthetic Studies Inspired by Vinigrol

Vinigrol, a diterpene natural product, has been a fascinating target for total synthesis for over two decades. This minireview describes recent synthetic studies that have ultimately allowed access to the coveted vinigrol scaffold. Barriault's synthesis of the vinigrol core is described, in addition to the elegant strategies disclosed by Njardarson and Hanna. The first total synthesis of vinigrol, reported by Baran in 2009, is also highlighted. This review showcases the fundamental role that natural products play in spawning innovations in synthetic chemistry.