Key result
Intersecting 2D cine DENSE MRI accurately derives the full 3D Lagrangian strain tensor.
A novel method accurately derives full 3D Lagrangian strain tensors from two intersecting 2D DENSE MRI measurements, enabling comprehensive myocardial mechanics analysis with short scan times.
May enable 3D strain analysis in routine 2D scans; leaves open clinical validation before diagnostic or therapeutic use.
A quantitative analysis of myocardial mechanics is fundamental to the understanding of cardiac function, diagnosis of heart disease and assessment of therapeutic intervention. In clinical practice, most cardiac imaging analyses are performed in 2D because of the limited scan time available. However, the obtained information from a 2D measurement is limited. This study presents a method to obtain temporal evolutions of transmural 3D Lagrangian strains from two intersecting 2D planes of slice-followed cine displacement encoding with stimulated echoes (DENSE) data using a bilinear-cubic polynomial element to resolve strain from the displaced myocardial positions. The method was validated against an analytical standard and has been applied to in vivo data acquired on a 3 T magnetic resonance system from a healthy volunteer to quantify systolic strains at the anterior-basal region of left ventricular myocardium. The method demonstrates accurate results when validated in the analytical model, and the in vivo results agree within experimental accuracy with values reported in the literature. Even with a short scan time, this method provides the full 3D Lagrangian strain tensor from two 2D DENSE measurements.
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Kindberg et al. (2011) studied Healthy (n=1). Method to obtain temporal evolutions of transmural 3D Lagrangian strains from two intersecting 2D planes of slice-followed cine DENSE data vs. Analytical standard and literature values was evaluated on Accuracy of 3D Lagrangian strain tensor measurement. A novel method using two intersecting 2D planes of slice-followed cine DENSE MRI accurately provided the full 3D Lagrangian strain tensor, agreeing with analytical models and literature values.
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