Three New Megastigmane Glycosides from Hylomecon vernalis

in mountainous regions of Korea, and China.1,2 H. vernalis has been used as Chinese folk medicine for the treatment of arthritis, neuralgia, and eczema.3 Previous phytochemical and pharmacological studies on this plant reported the isolation of several alkaloids and reported them to have anti-inflammatory, antispasmodic, antimicrobial, and anti-tumoral activities.3,4 Column chromatographic purification of the BuOH-soluble fraction of the MeOH extract of the aerial parts of H. vernalis led to the isolation of three new mega-stigmane glycosides (1-3), together with four known com-pounds (4-7). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectral analy-ses. The structures of the known compounds were identified to be (6R, 9R)-3-oxo-α-ionyl-9-O-α-L-rhamnopyranosyl-(1"→2')-β-D-glucopyranoside (4),5 (6R, 9R)-9-hydroxy-megastigman-4-en-3-one 9-O-α-L-rhamnopyranosyl-(1"→2')-