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October 1, 1988Nucleosides and Nucleotides

The reaction of Tetrazole with Phosphoramidites as a Model for the Nucleotide Coupling Step

S. Berner K. Mtihlegger H. Seliger

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Abstract

The mechanism of the tetrazole-activated coupling step in the synthesis of oligonucleotides via phosphorami-dites is studied with the help of model reactions.

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Berner et al. (1988) studied this question.

synapsesocial.com/papers/6aa53d0f246eab12a27f212f https://doi.org/10.1080/07328318808056326

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Synapse has enriched 5 related papers. Consider them for comparative context:

1Synthesis of deoxyoligonucleotides on a polymer supportOriginal Research · 1981 · 889 citations
2Modification of guanine bases by nucleoside phosphoramidite reagents during the solid phase synthesis of oligonucleotidesOriginal Research · 1985 · 60 citations
3LXIV.—Silicon researches. Part XI. SilicotetrapyrroleOriginal Research · 1909 · 17 citations
4Mechanistic studies on the phosphoramidite coupling reaction in oligonucleotide synthesis. I. Evidence for nudeophilic catalysis by tetrazole and rate variations with the phosphorus substituentsOriginal Research · 1987 · 83 citations
5Crystal and Solution Structure of 5′-O-(Guanosine-2′-O-Phosphonomethyl)Cytidine, an Isopolar Nonisosteric Phosphonate Analog Of GpCNucleosides and Nucleotides · Mon,

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