Key result
Fourteen single-nucleotide polymorphisms previously associated with diabetic kidney disease were not specific for DKD and may confer risk for chronic kidney disease of different etiologies (P=0.018).
Why the study?
The genetic backgrounds of diabetic kidney disease and end-stage kidney disease remain incompletely elucidated, and it is unclear whether single-nucleotide polymorphisms associated with DKD are disease-specific.
Are single-nucleotide polymorphisms previously associated with diabetic kidney disease specific to this etiology, or do they confer risk for end-stage kidney disease of other causes?
Case-Control (n=257)
Are single-nucleotide polymorphisms previously associated with diabetic kidney disease specific to this etiology, or do they confer risk for end-stage kidney disease of other causes?
p-value: p=0.018
SNPs previously linked to diabetic kidney disease may not be disease-specific and could confer risk for chronic kidney disease of other etiologies.
BACKGROUND: The genetic backgrounds of diabetic kidney disease (DKD) and end-stage kidney disease (ESKD) have not been fully elucidated. AIM: To examine the individual and cumulative effects of single-nucleotide polymorphisms (SNPs) previously associated with DKD on the risk for ESKD of diabetic etiology and to determine if any associations observed were specific for DKD. METHODS: Fourteen SNPs were genotyped in hemodialyzed 136 patients with diabetic ESKD (DKD group) and 121 patients with non-diabetic ESKD (NDKD group). Patients were also re-classified on the basis of the primary cause of chronic kidney disease (CKD). The distribution of alleles was compared between diabetic and non-diabetic groups as well as between different sub-phenotypes. The weighted multilocus genetic risk score (GRS) was calculated to estimate the cumulative risk conferred by all SNPs. The GRS distribution was then compared between the DKD and NDKD groups as well as in the groups according to the primary cause of CKD. RESULTS: = 0.018). CONCLUSION: Our results suggest that selected SNPs that were previously associated with DKD may not be specific for DKD and may confer risk for CKD of different etiology, particularly those affecting renal glomeruli.
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Saracyn et al. (2021) conducted a case-control in Diabetic kidney disease and end-stage kidney disease (n=257). 14 single-nucleotide polymorphisms (SNPs) previously associated with DKD vs. Non-diabetic ESKD was evaluated on Distribution of alleles and weighted multilocus genetic risk score (GRS) (p=0.018). Fourteen single-nucleotide polymorphisms previously associated with diabetic kidney disease were not specific for DKD and may confer risk for chronic kidney disease of different etiologies (P=0.018).
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